Technology licensed by Axolotl Biologix awarded NIH grant for research and development of bioengineered wound-healing solution for diabetes patients

NIH.jpg

Research to focus on the development of membrane dressing to accelerate wound closure and improve scar tissue strength and flexibility

 (PHOENIX) – Phoenix-based biotechnology company Axolotl Biologix, an innovator in regenerative medicine technologies, announced that technology it has exclusively licensed has been awarded a $224,500 grant funded by the National Institutes of Health (NIH) for the research and development of a wound-healing device for chronic wounds in patients suffering from diabetic foot ulcers.

This research addresses a critical market need by providing a bioengineered wound-healing device that can be used as a sole therapy and to prevent future limb complications. The development of this bioengineered membrane dressing will mimic the biochemical and mechanical characteristics of healthy human skin to stimulate the regrowth of skin cells, facilitate accelerated closure of wounds, and improve the strength and flexibility of the resulting scar tissue.

Research and development will be done collaboratively between Axolotl Biologix and Flagstaff, Arizona-based Protein Genomics, a biotechnology company that focuses on the research and development of biopolymers and their applications in wound healing and tissue regeneration.

“This grant enables the collaboration, research and eventual development of a bioengineered wound-healing solution made from native proteins and an elastin component into a composition designed to mimic human skin architecture,” said Bob Maguire, CEO of Axolotl Biologix. “Creating an innovative, biomimetic wound-healing therapy that promotes rapid healing for diabetic patients will minimize the chance of infection, improve the tensile strength of the skin in the affected area and reduce progressive tissue necrosis.”

Research on an innovative, new wound-healing treatment builds upon previously completed studies in a murine model that demonstrated the rapid closure of wounds, complete epithelization, and remodeled tissue that more closely resembled native skin. This research focuses on the synthesis of membranes containing genetically engineered tropoelastin and collagen mixtures to resemble the protein composition and structure of human skin, with the resulting scar tissue being stronger and more flexible due to the presence of elastin and less prone to subsequent failure or recurrence.

Phase 1, which will be completed within a 12-month timeframe, will consist of a series of experiments, evaluations and assessments in a pre-clinical diabetic wound model. Future Phase 2 work (not yet funded), which is expected to take between 12-24 months, will focus on the commercial development of an innovative solution for the treatment of diabetic wounds that will translate into improved clinical outcomes for diabetic patients.

“Foot ulcers and chronic wounds remain a treatment challenge for diabetic patients,” stated Burt Ensley, PhD, CEO of Protein Genomics. “The development of a more effective, biomimetic wound-healing therapy for the rapid closure of chronic wounds will result in less recurrence of diabetic foot ulcerations and substantially less scarring.”

Maguire added, “Chronic wounds in patients suffering from diabetes is a significant public health problem that affects over 30 million patients in the United States. Developing an innovative wound-healing therapy will be a novel solution for the treatment of chronic diabetic wounds.”

Rapidly building a portfolio of unique, patented regenerative-treatment products, Axolotl Biologix recently announced the launch of AxoBioFluid® A, its third amniotic allograft product providing significant improvements in patient outcomes, while delivering high value for clinicians. AxoBioFluid A is an ambient (room temperature) amniotic allograft fluid that is an alternative to its existing cryopreserved AxoBioFluid. Both products are media conditioned by amniotic mesenchymal stromal cells (MSC), and amniotic epithelial cells (AEC); which contain associated growth factors that are released during cell culture. These growth factors have significant regenerative benefits when used as a treatment for various injuries and degenerative conditions. Additionally, these fluids are immune-privileged in utero; therefore, they assist with repair of soft tissue without the chance of immunorejection.

 About Axolotl Biologix, Inc.

Axolotl Biologix, Inc. is an innovative biotechnology leader in regenerative medicine through research, technology and clinical application. Axolotl Biologix is expanding the human body’s ability to regenerate by developing and manufacturing regenerative human cell and tissue medical technologies that are disrupting traditional, more invasive, painful, and expensive treatment protocols. For more information, visit www.axobio.com.

About Protein Genomics

Protein Genomics carries out research and development on sophisticated, high-performance biopolymers for potential applications in the wound healing, tissue regeneration, dermal filler and personal care markets. For more information, visit www.proteingenomics.com.

Research reported in this news release was supported by the National Institute of Diabetes and Digestive and Kidney Disease of the National Institutes of Health under Award Number RK1DK112315. The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Institutes of Health.

###

 Follow Axolotl Biologix on social media:
Twitter: @axolotlbiologix
Facebook: www.facebook.com/axobio
LinkedIn: www.linkedin.com/company/7963036
Instagram: www.instagram.com/axobio

 

Learn more:
www.axobio.com
info@axobio.com
602.334.1298

Axolotl Biologix at the 2017 BioInterface Conference in San Diego

IMG_2365.jpg

Dr. Rob Diller presented on "Novel Wound Healing Devices Fabricated with Human Tropoelastin." This presentation specifically addresses Axolotl Biolgix' fourth product that will be an extracellular matrix that will have applications in wound care.

IMG_2343.jpg

Dr. Rob Kellar was the Chair of Anti-Infective Technologies and Wound Healing session at the 2017 BioInterface Conference in San Diego this past week.

Axolotl Biologix Launches AxoBioFluid® A an Ambient Temperature Amnion-Derived Allograft Fluid

axolotl png.png
 

Phoenix – September 13, 2017 -- Axolotl Biologix, an innovator in regenerative medicine technologies that improve patient outcomes with less pain and lower costs, today announced that it will begin shipping its third amniotic allograft product, AxoBioFluid® A on October 1st of this year.

AxoBioFluid® A is an ambient (room temperature) amniotic allograft fluid that is an alternative to the existing cryopreserved AxoBioFluid®. Both products are media conditioned by amniotic mesenchymal stromal cells (MSC), and amniotic epithelial cells (AEC); which contain associated growth factors that are released during cell culture. These growth factors, essential for fetal growth and development, have significant regenerative benefits when used as a treatment for various injuries and degenerative conditions. Both AxoBioFluid® products contain growth factors and cytokines that have been described in the peer-reviewed literature as anti- inflammatory, anti-fibrotic, vascular promoting, and proliferative. Additionally, these fluids are immune-privileged in-utero; therefore, AxoBioFluid® is able to assist with soft tissue repair without the chance of immunorejection.

AxoBioFluid® A is available for order immediately and will start shipping on October 1st. The product is available in four standard sizes 0.5ml, 1.0ml, 1.5ml, and 2.0ml, as well as custom sizes which may be ordered.

“AxoBioFluid® A meets our customer demand to have an injectable product that can be stored at room temperature, ready for use, and has an extended shelf life. This is another example of our focus on providing significant improvements in patient outcomes, while delivering high value for clinicians,” noted Bob Maguire, founder and CEO of Axolotl Biologix.

About Axolotl Biologix, Inc.

Axolotl Biologix, Inc., is expanding the human body’s ability to regenerate by developing and manufacturing regenerative human cell and tissue medical technologies that are disrupting traditional, more invasive, painful, and expensive treatment protocols. The Phoenix-based company is rapidly building a portfolio of unique, patented regenerative treatment products to improve patient outcomes with less pain and lower costs. For more information, please visit the company’s website at www.axobio.com.

Media:pr@axobio.com

Bob Maguire

602-354-3081

Axolotl Biologix to Exhibit at BIO International Convention 2017 in San Diego

 Axolotl Biologix to Exhibit at BIO International Convention 2017 in San Diego

Phoenix – June 12, 2017 - Axolotl Biologix, Inc., a biotech company that focuses on research and technology to enhance regenerative medicine, announced today that it will be exhibiting at the BIO Conference. The conference will be held June 19th-23rd at the San Diego Convention Center in San Diego, California. Axolotl Biologix will be exhibiting in the Arizona Pavilion at Booth 5519.

Axolotl Biologix’ CEO Bob Maguire stated, “We are excited to be a part of this event with over 17,000 attendees from around the world. We have dozens of meetings scheduled and are hoping to gain partnerships and opportunities to acquire more intellectual property.”

About Axolotl Biologix, Inc.

Axolotl Biologix, Inc. is a biotech company that develops and manufactures human cell and tissue products for orthopedic, wound care, podiatric, and aesthetic markets. The Company’s currently has two products to market. The first is it’s AxoBioFluid®, which is an amniotic allograft cryopreserved liquid that advances soft tissue repair, replacement, and reconstruction. The second is it’s AxoBioMembrane™, which is an amniotic allograft membrane used for wound care and surgical applications. The Company’s vision is to be an innovative and global leader in regenerative medicine through research, technology, and clinical application. 

For more information, please visit Axolotl Biologix’ website at www.axobio.com

SOURCE Axolotl Biologix, Inc.

Media:

PR@axobio.com

602-334-1298 ext. 1

Axolotl Biologix Launches AxoBioMembrane™ to Expand Amnion-Derived Allograft Products for Wound Care

Membrane.jpg

Phoenix – May 2, 2017 -- Axolotl Biologix, an innovator in regenerative medicine technologies that improve patient outcomes with less pain and lower costs, today announced that it has begun shipping its second amniotic allograft product, AxoBioMembrane™, to meet a wide range of wound care needs.

AxoBioMembrane is a dehydrated human amniotic membrane allograft that helps accelerate and improve soft tissue repair, while helping inhibit bacteria and infection, inflammation, and scar tissue formation. Containing extracellular matrix components and providing a natural biological wound barrier, AxoBioMembrane offers many clinical applications in wound care for surgical, orthopedic, podiatric, ophthalmic, maxillofacial and other applications.

AxoBioMembrane is available for order immediately in three standard sizes 1x2 cm, 2x3 cm, and 4x4 cm, as well as custom sizes which may be ordered.

“Launching our second new amnion-derived product so far this year, we are excited to be rapidly building a portfolio of regenerative treatment products that provide significant improvement in patient outcomes, while delivering high value for clinicians,” noted Bob Maguire, founder and CEO of Axolotl Biologix.

About Axolotl Biologix, Inc.

Axolotl Biologix, Inc., is expanding the human body’s ability to regenerate by developing and manufacturing regenerative human cell and tissue medical technologies that are disrupting traditional, more invasive, painful, and expensive treatment protocols.  The Phoenix-based company is rapidly building a portfolio of unique, patented regenerative treatment products to improve patient outcomes with less pain and lower costs.  For more information, please visit the company’s website at www.axobio.com.

 

Media:

bsamson@axobio.com

714-955-3951

Axolotl Biologix Appoints Robert S. Kellar Ph.D., as Chief Science Officer

Phoenix – March 9, 2017 -- Axolotl Biologix, an innovator in regenerative medicine technologies that improve patient outcomes with less pain and lower costs, today announced the appointment of Robert S. Kellar, Ph.D., as Chief Science Officer. Dr. Kellar will be overseeing Axolotl Biologix’s research and product development efforts, bringing over 16 years of research and clinical development experience from medical device and biotechnology companies.

Most recently, Dr. Kellar served as an Advisory Board Member for Protein Genomics, Inc., a biotechnology company that focuses on research and development of biopolymers and their applications in wound healing, tissue regeneration, dermal fillers, and personal care markets. Dr. Kellar had a key role for building out the research program for Protein Genomics’ Elastatropin® an extracellular matrix protein that is an extremely important component of skin that provides strength and elasticity. 

Dr. Kellar will continue as an Associate Professor of Practice in Biological Sciences at the Center for Bioengineering Innovation at Northern Arizona University, and as the Co-Director of the Bioengineering PhD Program, the Co-Director of the Imaging & Histology Core Facility, and an adjunct faculty member in Mechanical Engineering. Dr. Kellar's academic laboratory is called the Tissue Engineering & Regenerative Medicine (TERM) Laboratory. His lab focuses on biomaterials, biocompatibility, cell & tissue culture, stem cell biology, and wound healing.

Dr. Kellar is the Founder and President of Development Engineering Sciences, LLC, a biomedical consulting firm. He has experience in the development and regulatory approval of medical devices, cell-based products, and tissue engineered technology. Previously, Dr. Kellar was VP of Research and Development at Histogen, Inc. where he led multi-functional project teams for all aspects of product development. Prior to Histogen, Dr. Kellar was a product specialist for the first FDA-approved thoracic endograft at W.L. Gore and Associates where he served in a lead role in development, regulatory, clinical trials, marketing, sales, and business for the thoracic device and the product portfolio. Previous to this position, Dr. Kellar was a product specialist for the Global Oral Health Business at W.L. Gore & Associates (both Gore-Tex® Regenerative Membranes and the entire resorbable membrane portfolio). Prior to Gore, at Advanced Tissue Sciences, Inc. he led cardiovascular research programs and managed the Anginera® program.

Dr. Kellar previously served on the Scientific Advisory Board for Theregen and the Advisory Board for Flagship Biosciences, a digital pathology company he helped co-found. He currently serves on the Scientific Advisory Board for MyoStim, the Board of Directors for the Surfaces in Biomaterials Foundation, the Advisory Board for Protein Genomics, and the Advisory Board for the California Stock Xchange. He earned his Ph.D. in 2001 in Physiological Sciences from the University of Arizona in the Biomedical Engineering Laboratory of Dr. Stuart K. Williams. Dr. Kellar is 42 years old.

“The role of biologics in regenerative medicine is one of the most promising new avenues for dramatic improvements in patient outcomes and comfort in the treatment for burns, surgical resections, trauma, and chronic wounds, as well as aesthetic medicine,” said Dr. Kellar. “I look forward to helping Axolotl Biologix rapidly move into a leadership position for research, development, and the clinical applications of new regenerative biotechnologies.”

About Axolotl Biologix, Inc.

Axolotl Biologix, Inc., is a developer of innovative regenerative human cell and tissue medical technologies that is disrupting traditional painful and expensive treatment regimens for burn, surgical, trauma and chronic wounds. The company is rapidly building a portfolio of unique patented regenerative treatment products to improve patients’ outcomes with less pain and lower costs. Founded in 2016 by Bob Maguire, AxoBio already has two products in production. AxoBioFluidTM, a cryopreserved liquid allograft, and AxoBioMembraneTM, an amniotic allograft membrane patch, are targeted to advancing soft tissue repair, replacement and reconstruction. For more information, please visit the company’s website at www.axobio.com. Axolotl Biologix is headquartered in Phoenix, 1637 Knudsen Drive, Phoenix, AZ 85027.

Media:

PR@axobio.com 

602-334-1298, x-11